PhD Student: Translational Research on Metabolic Diseases

Popis:

The Department of Medical Sciences is a large clinical institution with approximately 250 employees and over 900 individuals affiliated through Academic Hospital. The department has a broad research profile with strong research groups across multiple areas. Research is conducted in close connection with clinical operations at Academic Hospital and encompasses both fundamental studies on disease mechanisms and development and evaluation of improved diagnostics and new treatment methods. More information about the department is available at https://www.uu.se/institution/medicinska-vetenskaper/ Project Description: The Unit for Clinical Diabetology and Metabolism conducts both clinical and experimental research projects focused on type 2 diabetes and obesity. We have well-developed interdisciplinary collaborations locally and nationally/internationally (e.g., SSF centers and EU Horizon programs). Type 2 diabetes is an increasing public health problem worldwide. The disease is characterized by impaired insulin production combined with insulin resistance. Obesity plays an important role in the development of insulin resistance, type 2 diabetes, and metabolic syndrome. In addition to storing energy, adipose tissue also functions as an endocrine organ and communicates with other organs, particularly the brain. The overarching goal of this project is to identify new mechanisms in the interaction between the brain and peripheral tissues, particularly adipose tissue and the gastrointestinal tract, which may contribute to insulin resistance, obesity, and type 2 diabetes. We use various methods: - Brain imaging and imaging of other organs in humans in vivo, during hormonal/metabolic tests - Investigation of dynamic regulation of various hormone systems in the development of type 2 diabetes - Experimental studies of metabolism and other functions in human adipose tissue. These include cellular signaling, pharmacology, and omics methods. We will perform analysis of tissue samples with respect to, among other things, morphology, nerve activity and neurotransmitters, cell differentiation, glucose and lipid metabolism, insulin signaling, and expression of relevant genes important for type 2 diabetes and obesity. Clinical examinations with hormone challenge tests are conducted on patients and healthy individuals, often with simultaneous imaging of activity in the brain and other organs, using PET and MRI techniques. These studies are expected to lead to new methods for prevention and treatment of obesity and type 2 diabetes. Duties: The primary responsibility for a PhD student is to conduct research projects and doctoral training courses (30 credits). You will collect, analyze, compile, and present results from blood and tissue samples and clinical examinations. Participation in experimental laboratory work and clinical investigations of metabolism and hormones. The duties may also include teaching and certain departmental work, but not more than 20% of working time. Qualification Requirements: Eligibility for doctoral-level education in this field is granted to those who have: - Completed a degree at the advanced level in medical science, biomedicine, or similar, or - Completed at least 240 higher education credits, of which at least 60 higher education credits at the advanced level including an independent project of at least 15 higher education credits, or - Acquired primarily equivalent knowledge in another documented manner Applicants must also have: - Good ability to collaborate as well as work independently - Good analytical skills, personal drive, and flexibility - Excellent English language skills, both written and spoken Meritorious: - Experience with cell biological methods and imaging methods in vitro and/or in vivo - Advanced studies in metabolic/endocrine diseases - Experience with experimental/translational research in energy metabolism, particularly hormonal regulation at the cellular and tissue levels We place great emphasis on personal qualities such as accuracy and responsibility as well as good communication and organizational skills. Regulations for PhD students are found in the Higher Education Ordinance Chapter 5, Sections 1-7 and in the university's rules and guidelines http://regler.uu.se/. About the Position: The employment is fixed-term, according to HF Chapter 5, Section 7. Full-time position. Start date by agreement. Work location: Uppsala Information about the position is provided by: Prof Jan Eriksson, [email protected] or Associate Professor Maria Joao Pereira, [email protected] Welcome to submit your application no later than June 26, 2026, UFV-PA 2026/1970 Please enclose CV and contact information for two reference persons. Uppsala University is a broad research university with a strong international reputation. The ultimate goal is to conduct education and research of the highest quality and relevance to make a difference in society. Our most important asset is all 7,500 employees and 53,000 students who with curiosity and commitment make Uppsala University one of the country's most exciting workplaces. Read more about our benefits and what it is like to work at Uppsala University https://uu.se/om-uu/jobba-hos-oss/ The employment may be subject to security clearance. Security clearance is a prerequisite for employment and the applicant must be approved. We decline offers of recruitment and advertising assistance. Applications are received in Uppsala University's recruitment system. Trade union representatives: Saco-S - [email protected], Seko - [email protected], ST (OFR/S) - [email protected]

Přehled

Typ

job

Stav

active

Viditelnost

public

Město

Uppsala

Adresa

Box 256

GPS

59.8520701, 17.7188369kopírovatotevřít v ▾

Email

[email protected]

Zobrazení

5

Publikováno

16. 6. 2026

Upraveno

21. 6. 2026

Parametry